Troubled Valencia's joy at beating Chelsea in the Champions League in midweek was punctured by a disappointing 1-1 draw at home to Leganes.
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Atletico Madrid made it two wins out of two as Vitolo scored in the second half to secure a hard-fought 1-0 La Liga victory.
Leganes dented Sevilla's bid to qualify for next season's Champions League with an emphatic 3-0 away win on Friday in La Liga.
Real Madrid needed a Karim Benzema second-half goal to secure a 1-1 draw at Leganes in La Liga action on Monday.
How do you beat Barcelona? Ask Leganes boss Mauricio Pellegrino. "In society, there's a huge disparity but in soccer, you can fight with equality."
Atletico Madrid kept up their pursuit of La Liga leaders Barcelona by beating Leganes 1-0 at home on Saturday.
Fenerbahce defender and Mexico international Diego Reyes has been loaned to La Liga side Leganes until the end of the season.
Lionel Messi came off the bench to inspire Barcelona to a 3-1 win over a dogged Leganes side on Sunday, creating one goal and scoring another.
Danish forward Martin Braithwaite struck the only goal of the game on the half-hour mark, finishing into an empty net from close range.
Real Madrid pulled away from Leganes in the second half for a 3-0 win in their Copa del Rey first-leg tie on Wednesday.
Wissam Ben Yedder scored in stoppage time to snatch a 1-1 draw for 10-man Sevilla at Leganes in La Liga on Sunday.
Alaves spurned the chance to go top of La Liga on Friday with a 1-0 defeat at Leganes, who moved out of the relegation zone.
Atletico Madrid threw away the chance to go top of La Liga by conceding a late equaliser to draw 1-1 away to neighbours Leganes on Saturday.
Antoine Griezmann gave Atletico Madrid the lead away at Leganes but they were pegged back when the hosts equalised late on.
Barca fell to their first loss of the season at the Butarque stadium as Leganes chalked up their first win.
Two second-half goals gave Leganes a shock 2-1 win over Barcelona on Wednesday night, the first loss on the season for the Catalan giants.
Real Madrid continued their flying start to the La Liga season by easily beating neighbours Leganes 4-1 helped by a Karim Benzema double Saturday.
Real Madrid have confirmed that teenage goalkeeper Andriy Lunin has joined Leganes on loan.
With the new La Liga season just a few days old, CD Leganes have welcomed back Super Pepino -- a giant, seven-foot tall cucumber.
Nigeria international defender Kenneth Omeruo completed a season-long loan from Chelsea to Spanish side CD Leganes on Wednesday.
Jose Arnaiz joins from Barcelona for an initial €5 million, with loan deal sealed for Real Madrid playmaker Oscar Rodriguez.
Bournemouth have signed defender Diego Rico from Spanish side Leganes on a four-year contract, the Premier League club have said.
Former Southampton manager Mauricio Pellegrino was named as the new boss of La Liga side Leganes on Saturday.
Real Sociedad have named Asier Garitano as their new head coach.