Donaldson homered against Sean Doolittle in the top of the 10th inning, and the Braves pulled out a 5-4 victory over the Washington Nationals on Wednesday to take two of three in the series and pad their division lead to 6 1/2 games.
"It felt good," Donaldson said. "You know, 0-for-4 with two (strikeouts) before that. I was able to put a good swing together and help our team win the game."
After the Nationals scored twice in the bottom of the ninth to tie the game, Donaldson swatted a fastball from Doolittle (6-3) over the center-field wall for his 25th homer of the season.
"I know what he features," Donaldson said of the Washington closer and his former teammate on the Oakland A's. "He had gotten me out two times before that. Today, it was my turn."
"Shane Greene has a 1.00 ERA. So, I think anyone would take him," first baseman Freddie Freeman said of the All-Star. The Braves acquired Greene for a pair of minor-league prospects.
Adam Duvall homered for the fourth time in five games. Ronald Acuna Jr., Ozzie Albies and Tyler Flowers also drove in runs for the Braves, who went 4-2 on a road trip through Philadelphia and Washington, their top challengers for the NL East title.
Atlanta won consecutive series in Washington for the first time since 2013. They also won two of three in late June.
"I don't get tired of watching that offense," manager Brian Snitker said. "It's amazing how they keep fighting. You know, it was tough to lose the lead in the ninth. But they just keep coming back."
That caused his road ERA to climb to 1.20 in 11 starts this season. That's still the best by a Braves pitcher since Greg Maddux posted a 1.12 mark over 15 starts in 1995.
Washington starter Anibal Sanchez allowed four runs on 10 hits in five innings.
The Nationals rallied against the Braves' bullpen.
In the ninth, Kurt Suzuki singled in a run off Sean Newcomb (5-1), who replaced Luke Jackson with no outs and two runners on. Newcomb limited the damage from there, however, getting a double-play grounder from Gerardo Parra that tied the game at 4.
"These guys play hard," manager Dave Martinez said. "They don't quit. They keep fighting, and they play hard to the end. We just fell short today."
Josh Tomlin worked a scoreless 10th for his second save.
Duvall homered off Sanchez with one out in the second to continue a torrid stretch.
Since being recalled from Triple-A Gwinnett on July 27 after Nick Markakis broke his left wrist, Duvall is batting .578 with four homers and six RBI over five games.
Soto's homer to lead off the second was his 20th, making him the third player in major league history with two 20-homer seasons before his 21st birthday. It was also the sixth consecutive game he has driven in a run, the longest such streak of his career.
The Nationals have the worst bullpen ERA in the majors at 5.97.
Nationals: 1B Ryan Zimmerman (plantar fasciitis) took 15-20 swings in the batting cage Tuesday and could return soon, manager Dave Martinez said.
Braves: LHP Max Fried (11-4, 4.21) aims for his third straight victory as Atlanta opens a four-game home series against Cincinnati.
Nationals: RHP Joe Ross (0-3, 9.85) will make his first career start in Arizona on Friday, as the Nationals begin a nine-game road trip with the first of three against the Diamondbacks.
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