Carey's 3-pointer with 8:44 before halftime made it 23-21 in favor of Siena and the Saints never trailed again. The Saints led 45-37 at halftime, and Pickett's jump shot with 10:07 left extended the lead to 55-44 before the Crusaders used a 7-0 run to close within four but they never got closer.
Elijah Burns scored 17 for Siena, which shot 29 of 54 (53.7%).
Holy Cross begins Patriot League action when it travels to Loyola (MD) on Thursday.
Siena (5-5, 1-0 Metro Atlantic Athletic Conference) hosts Monmouth on Friday.
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