Marquell Carter led the Golden Lions (0-4) with 20 points and nine rebounds as Arkansas-Pine Bluff trailed by just six points with nine minutes left in the game.
This was Arkansas-Pine Bluff's closest margin of defeat this season.
Neither team took care of the ball very well as Kansas State had 16 turnovers compared to Arkansas-Pine Bluff's 20.
A zone defense by the Golden Lions proved to be troublesome and the Wildcats posted the fewest point total in a home game this season.
Kansas State was able to make a season high eight 3-pointers and held the Golden Lions to just three.
Both teams had a 12-0 run in the first half, and they were squared at 27 after 20 minutes.
Kansas State has yet to be leading at the half in any game this season.
Montavious Murphy didn't play for the Wildcats due to an undisclosed injury he sustained against Monmouth last week. He averages five points and five rebounds this season.
Arkansas-Pine Bluff had too many turnovers to hang with the Wildcats but showed promise after a poor start to the season.
Kansas State's first half woes continued, but they were able to pull away in the second half.
Arkansas-Pine Bluff plays its third game in six days Thursday when they face Pittsburgh.
Kansas State will take part in the Fort Myers Tipoff in Florida when they face Pittsburgh on Monday.