The Panthers (7-11, 5-0 Southwestern Athletic Conference) now have won six straight, the longest streak during coach Bryron Smith's tenure. Prairie View won five straight last year.
Taishaun Johnson made a pair of free throws to give Prairie View a 19-13 lead and that started a 19-4 run for the Panthers. They led 48-19 at halftime with 18-made field goals as they distributed 11 assists. Eight different players entered the scoring column as Grambling (9-10, 3-3) turned it over 18 times while shooting 7 of 15 from the field.
Johnson and Devonte Patterson each scored 13 for the Panthers.
Ivy Smith Jr. scored 17 points for Grambling, which finished with 26 turnovers and 29 fouls, and Axel Mpoyo scored 10 with 11 rebounds. The Tigers never got closer than 11 points in the second half.
Morant plays with a chip on his shoulder
Ja Morant describes how it feels to be in the NCAA tournament and when he first felt like he was overlooked.
Giant Killers' 10 most likely first-round upsets
Looking for a first-round upset? The Giant Killers model has several possibilities, including Ja Morant and Murray State pulling off a surprise.
Who will be taking home the national title?
Dick Vitale, Jay Bilas, Seth Greenberg, Jay Williams and Rece Davis share their predictions for who is going to survive and capture the men's basketball national title.