McCarthy and Ferrari combined to shoot 15 of 19 from the field and Ferrari made four 3-pointers. San Francisco finished shooting 30 of 55 (54.5 percent) and committed just six turnovers.
The Dons (17-3, 5-1 West Coast Conference) built a 25-10 lead and were never challenged. They shot 17 of 28 (60.7) from the field in the first half and led 42-21 at halftime as Portland missed all six of its 3-point shot attempts.
Portland (7-14, 0-6) now has lost seven straight and nine of its last 10. Marcus Shaver Jr. led the Pilots with 13 points and Jacob Tryon scored 11.
No. 12 Seton Hall aims to bounce back at Saint Louis
After a loss to Michigan State in a game that had all the madness of March, No. 12 Seton Hall faces another tough challenge on Saturday.
No. 14 Oregon aims to cap big week vs. Texas-Arlington
The Oregon Ducks are flying high after a quality win, and look to keep their momentum when they welcome Texas-Arlington to Eugene, Ore. on Sunday.
No. 15 Florida heads to UConn still looking for offense
The No. 15 Florida Gators hit the road for the first time this season, hoping to hit their stride on offense when they play the Connecticut Huskies on Sunday in Storrs, Conn.